Tigecycline is the first glycycline antibiotic to be approved by the US Food and Drug Administration. The compound is active against a wide range of bacteria: e. The drug is unique for its ability to be used as monotherapy for empirical coverage of various drug resistant pathogens and polymicrobial infections. Because of poor oral absorption, tigecycline should be given parenterally At present, no vaccines against anaerobic bacteria are available.
The anaerobic bacteria consist a great part of the normal microflora and the immune response is therefore low. The two key approaches to treatment of infections involving anaerobic bacteria are surgery and antimicrobial therapy. In most anaerobic infections except pulmonary , surgical drainage and debridement are necessary for a favorable outcome. Failure to carry out essential surgical therapy may lead to poor or no response to appropriate antimicrobial agents. Most of the anaerobic bacteria involved in infection are present as normal flora at various sites in the human body, which makes prevention of anaerobic infections difficult.
Anaerobic bacteria are important pathogens in many different infections. New antimicrobial agents such as linezolid and tigecycline may be an alternative in the therapy of anaerobic infections. The treatment of anaerobic infections must be individualized, taking into account the site, type, extent and severity of the infection.
Empiric antimicrobial therapy is frequently used in the treatment of anaerobic infections as it might take several days for bacterial cultures to grow and, in many cases, the patient needs care without delay.
The antibiotic resistance patterns are no longer predictable in anaerobic bacteria and the first choice of antibiotic might not be sufficient. Antimicrobial susceptibility testing of the infecting microorganisms will give essential information of the alternatives for treatment. Multicenter survey of the changing in vitro antimicrobial susceptibilities of clinical isolates of Bacteroides fragilis group, Prevotella, Fusobacterium, Porphyromonas, and Peptostreptococcus species.
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